Although solitary or sensory cilia are present in most cells of the body and their existence has been known since the early sixties, very little is known about their function. One function that is suspected of fluid flow sensing- physical bending cilia generate influx of Ca ++, which Rat Clia Kits can then lead to a variety of signaling pathways activated. faulty cilia and cilia-related proteins has been shown to result in cystic disease. Autosomal dominant polycystic kidney disease (ADPKD) is a progressive disease, usually appearing on the 5th decade of life and is one of the most common monogenetic inherited human diseases, affecting approximately 600,000 people in the United States. Due to the mechanical properties of cilia impact their response to the applied stream, we asked how the ciliary stiffness can be controlled pharmacologically. We attempted to subdue the cilia to Taxol (a microtubule stabilizer) and CoCl2 (a model of hypoxia HIF stabilizers). Ma...